| Review of primary hypothyroidism in very low birthweight infants in a perinatal centre in Hong Kong. | |
| | |
MedLine Citation:
|
PMID: 21435074 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aims: To review the incidence and risk factors of primary hypothyroidism in very low birthweight (VLBW) infants in our centre and to assess their neurodevelopmental outcome. Method: Retrospective, descriptive review of VLBW infants with primary hypothyroidism from 1 January 2000 to 31 December 2008 in a perinatal centre. Case control comparisons for neurodevelopmental outcome at 18 months, nested to a prospective VLBW cohort (Vermont Oxford Database). Results: Twelve cases were identified, with the incidence of primary hypothyroidism of 1 in 55 live births in our VLBW cohort during the 9-year study period. Umbilical cord blood thyroid-stimulating hormone was abnormal in less than half of the cases using the current cut-off (≤14 mIU/L). Five cases were transient in nature, four cases were permanent and the causes for the rest remained undetermined at the time of review. Elevation of thyroid-stimulating hormone was first evident at a mean of 2.4 weeks post-natally. Follow-up assessment reviewed normal development in 83% of cases (10 out of 12 cases). There was no statistically significant difference in Griffith's scores at 18 months between the case and matched controls. Conclusions: The high incidence of primary hypothyroidism in our VLBW cohort deserved stringent monitoring of thyroid function post-natally. Umbilical cord blood screening was not useful as a screening tool because of its low sensitivity. Neurodevelopmental outcome for treated primary hypothyroidism was favourable as assessed at 18 months of age. |
| | |
Authors:
|
Yuet Yee Chee; Kar Yin Wong; Louis Low |
Related Documents
:
|
8358104 - Psoriasis and birdshot chorioretinopathy: response to aromatic retinoids. 9694064 - Acute transverse myelitis and primary urticarial vasculitis. 15706374 - Lupus vulgaris--report of a case with facial involvement. 14660264 - Mycophenolate in dermatology. 19011744 - Is family screening necessary in brucellosis? 225694 - Widespread intranuclear neuronal corpuscles (marinesco bodies) associated with a famili... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
|
Title: Journal of paediatrics and child health Volume: - ISSN: 1440-1754 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians). |
Affiliation:
|
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Addressing the well-being of Aboriginal children in out-of-home care: Are we there yet?
Next Document: Health-related quality of life in paediatric patients with inflammatory bowel disease related to dis...