Document Detail

Review of primary hypothyroidism in very low birthweight infants in a perinatal centre in Hong Kong.
MedLine Citation:
PMID:  21435074     Owner:  NLM     Status:  Publisher    
Aims:  To review the incidence and risk factors of primary hypothyroidism in very low birthweight (VLBW) infants in our centre and to assess their neurodevelopmental outcome. Method:  Retrospective, descriptive review of VLBW infants with primary hypothyroidism from 1 January 2000 to 31 December 2008 in a perinatal centre. Case control comparisons for neurodevelopmental outcome at 18 months, nested to a prospective VLBW cohort (Vermont Oxford Database). Results:  Twelve cases were identified, with the incidence of primary hypothyroidism of 1 in 55 live births in our VLBW cohort during the 9-year study period. Umbilical cord blood thyroid-stimulating hormone was abnormal in less than half of the cases using the current cut-off (≤14 mIU/L). Five cases were transient in nature, four cases were permanent and the causes for the rest remained undetermined at the time of review. Elevation of thyroid-stimulating hormone was first evident at a mean of 2.4 weeks post-natally. Follow-up assessment reviewed normal development in 83% of cases (10 out of 12 cases). There was no statistically significant difference in Griffith's scores at 18 months between the case and matched controls. Conclusions:  The high incidence of primary hypothyroidism in our VLBW cohort deserved stringent monitoring of thyroid function post-natally. Umbilical cord blood screening was not useful as a screening tool because of its low sensitivity. Neurodevelopmental outcome for treated primary hypothyroidism was favourable as assessed at 18 months of age.
Yuet Yee Chee; Kar Yin Wong; Louis Low
Related Documents :
17085354 - Dubin-johnson syndrome with systemic lupus erythematosus: a case report.
2528354 - High-grade atrioventricular heart block in an adult with systemic lupus erythematosus: ...
19162244 - The 100th anniversary of lupus erythematosus tumidus.
16929884 - A woman with cough, fever, and micronodular infiltrates on chest radiograph.
23119444 - Synovial sarcoma of the larynx.
19097524 - Abdominal wall endometrioma following cesarean delivery: a case report.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  -     ISSN:  1440-1754     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Addressing the well-being of Aboriginal children in out-of-home care: Are we there yet?
Next Document:  Health-related quality of life in paediatric patients with inflammatory bowel disease related to dis...