Document Detail

Review: potential role of cell cycle synchronizing agents in combination treatment modalities of malignant tumors.
MedLine Citation:
PMID:  15796159     Owner:  NLM     Status:  MEDLINE    
Malignant neoplasms consist of heterogeneous cell populations and their cellular elements proliferate asynchronously. Since the tumor cells of various cell cycle phases respond differently to many chemotherapeutic drugs, attempts at synchronization seemed to be a promising way to achieve a more powerful antineoplastic effect. Mainly based on in vitro data, it was shown that numerous compounds, including hormones, were able to arrest the cell cycle in different phases, and some of them also induced apoptotic cell death. The better understanding of the molecular mechanisms of cell cycle control has brought the cyclin-dependent kinases into focus and hundreds of compounds have been synthesized in order to regulate malignant cells at their checkpoints, especially at G1 progression. Some of these compounds have been found to be effective not only in vitro, but also in in vivo experiments, and they were further evaluated in Phase I - II clinical trials. Generally speaking, these studies have yielded modest, although potentially promising, results, but the adverse effects sometimes restricted the applicability of the products. Nevertheless, extended studies in cancer patients are under way. Moreover, after encouraging preclinical investigations, the combination of cell cycle regulators with different cytostatic drugs may offer a novel therapeutic alternative in the field of oncology.
Attila Zalatnai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  19     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-03-30     Completed Date:  2005-08-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
First Department of Pathology and Experimental Cancer Research, Semmelweis University, Faculty of Medicine, Budapest, Hungary.
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MeSH Terms
Antineoplastic Agents / administration & dosage,  pharmacology*,  therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  therapeutic use*
Apoptosis / drug effects
Cell Cycle / drug effects*
Cyclin-Dependent Kinases / drug effects
G1 Phase / drug effects
Neoplasms / drug therapy*
Reg. No./Substance:
0/Antineoplastic Agents; EC Kinases

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