Document Detail


Review of pharmacology and physiology in thrombolysis interventions.
MedLine Citation:
PMID:  22550379     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Reperfusion therapy using thrombolytic agents has been shown to be a safe and effective treatment strategy for arterial ischemia, venous thrombosis, massive pulmonary embolism, and acute stroke. Thrombolytic agents have evolved over the course of a few decades, from nonfibrin selective to fibrin-selective agents. The development and modification of these agents have resulted in improved understanding of their pharmacologic attributes, and their effects on the complex molecular events that occur during thrombolysis goal-directed therapies. The current review focuses on the physiology and pharmacology of the thrombolytic agents that have been or are currently in use for interventional thrombolysis interventions. Attention is also given to the particular role that thrombolytic agents play in the current management of peripheral vascular disease and acute stroke.
Authors:
M Grace Knuttinen; Neelmini Emmanuel; Furquaan Isa; Alex W Rogers; Ron C Gaba; James T Bui; Charles A Owens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in interventional radiology     Volume:  27     ISSN:  1098-8963     ISO Abbreviation:  Semin Intervent Radiol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8510974     Medline TA:  Semin Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-83     Citation Subset:  -    
Affiliation:
University of Illinois at Chicago Medical Center, Chicago, Illinois.
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