Document Detail

Review: pancreatic enzyme replacement--applied physiology and pharmacology.
MedLine Citation:
PMID:  2979686     Owner:  NLM     Status:  MEDLINE    
The treatment of pancreatic steatorrhoea can often be improved by attention to the pathophysiological and pharmacological principles involved. Factors influencing the efficacy of pancreatic enzyme replacement include physiological characteristics of the individual patient and pharmaceutical characteristics of the supplement. Different patients may be best suited by different preparations and there is no overall 'best buy'. The new enteric-coated microsphere formulations are often most effective, but also more expensive than conventional preparations. Adjunctive H2-blockade can help appropriately selected patients with resistant steatorrhoea. Knowledge of the underlying cause may guide the choice of supplement and its dose, but trials of different regimens may prove necessary. Successful management, particularly of malnourished patients, involves optimization of dietary fat intake in addition to enzyme replacement.
P L Zentler-Munro; T C Northfield
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  1     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1992-03-05     Completed Date:  1992-03-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-91     Citation Subset:  IM    
St. George's Hospital Medical School, London, UK.
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MeSH Terms
Pancreatic Diseases / drug therapy*,  physiopathology
Pancreatin / pharmacology*,  therapeutic use
Reg. No./Substance:

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