| Review on monogenic diabetes. | |
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MedLine Citation:
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PMID: 21844708 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The goal of this review is to provide an update on the different forms of monogenic diabetes, including maturity-onset diabetes of the young (MODY) and neonatal diabetes (permanent and transient neonatal diabetes). RECENT FINDINGS: Monogenic diabetes accounts for approximately 1-2% of diabetes cases and results from mutations that primarily reduce β-cell function. Individuals with islet autoantibody negative youth-onset forms of diabetes should be evaluated for either glucokinase-MODY or transcription factors MODY. The mild-fasting hyperglycemia found in glucokinase-MODY typically does not necessitate pharmacological treatment, whereas patients with MODY caused by transcription factor mutations can often be successfully treated with low-dose sulfonylurea. Neonatal diabetes is defined as diabetes onset within the first 6 months of life and most individuals with permanent neonatal diabetes can be treated with high-dose sulfonylurea. SUMMARY: The discovery of the genetic cause of monogenic diabetes has greatly advanced our understanding and management of these uncommon forms of diabetes. |
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Authors:
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Andrea K Steck; Wiliam E Winter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in endocrinology, diabetes, and obesity Volume: 18 ISSN: 1752-2978 ISO Abbreviation: Curr Opin Endocrinol Diabetes Obes Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
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Languages: eng Pagination: 252-8 Citation Subset: IM |
Affiliation:
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aBarbara Davis Center for Childhood Diabetes, University of Colorado Denver (UCD), Aurora, Colorado bDepartments of Pathology, Immunology & Laboratory Medicine, Pediatrics, and Molecular Genetics & Microbiology, University of Florida, College of Medicine, Gainesville, Florida, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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