Document Detail

Review of literature for the striking clinic picture seen in two infants of mothers with systemic lupus erythematosus.
MedLine Citation:
PMID:  21231845     Owner:  NLM     Status:  Publisher    
Fertility and maintanence of pregnancy is impaired in patients with SLE, which is an autoimmune disease commonly seen in women of childbearing age, due to disease-causing autoantibodies. The auto-antibodies transplacentally passing to the fetus may destroy the specific fetal tissues according to their types. These harmful effects may also continue in postnatal life. Here, we report two neonates born to mothers with SLE, and presented with clinically different pictures. The first case, who was born to a mother with asymptomatic SLE, had fetal arrhythmias in prenatal period, and developed complete AV block shortly after birth. Specific auto-antibodies of the mother and infant were positive. Permanent pacemaker was inserted into the infant. The second case was a completely healthy preterm infant who was born to a mother who had pre-eclampsia in pregnancy and diagnosed with SLE and class I lupus nephritis for 12 years. Severely affected infants may be born to asymptomatic mothers with SLE while the symptomatic mothers may have healthy babies. These contrasting clinical features of infants of mothers with SLE are associated with the type of disease-causing autoantibodies.
Mustafa Ali Akin; Ali Baykan; Sadettin Sezer; Tamer Gunes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Erciyes University, Kayseri, Turkey.
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