Document Detail

Review of isolated ascending aortitis: differential diagnosis, including syphilitic, Takayasu's and giant cell aortitis.
MedLine Citation:
PMID:  16916717     Owner:  NLM     Status:  MEDLINE    
The image of tree-barking and proximal aortic root dilatation is firmly entrenched in the minds of practising pathologists as representing syphilis until proven otherwise. We discuss the differential diagnosis of syphilitic aortitis, Takayasu's disease, and giant cell aortitis, with a review of the literature and brief overview of other types of aortitis. As a starting point, we report a case of non-specific, or idiopathic, aortitis with aneurysm that was initially misdiagnosed as syphilitic aortitis. We then review the literature and emphasise the lack of histological data and histopathological criteria for the diagnosis of non-infectious aortitis and the implications for treatment in cases of isolated aortitis. Tree-barking is a non-specific finding in aortitis of any aetiology, and syphilitic aortitis in developed countries is rare. It is still unclear if there are histological features that separate Takayasu's disease and giant cell arteritis. In the majority of patients presenting with aortic root aneurysms, aortitis is an isolated finding not associated with autoimmune disease. Despite a plethora of literature, a histological classification of aortitis has yet to be attempted.
Fabio Tavora; Allen Burke
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pathology     Volume:  38     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-18     Completed Date:  2006-10-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  302-8     Citation Subset:  IM    
Department of Pathology, University of Maryland, Baltimore, Maryland 21209, USA.
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MeSH Terms
Aorta / pathology*
Aortic Aneurysm / pathology
Aortitis / diagnosis*,  pathology*
Diagnosis, Differential
Giant Cell Arteritis / diagnosis*,  pathology
Syphilis, Cardiovascular / diagnosis*,  pathology
Takayasu Arteritis / diagnosis*,  pathology
Vasculitis, Central Nervous System / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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