| Review of functional/anatomical imaging in oncology. | |
| | |
MedLine Citation:
|
PMID: 22314804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Patient management in oncology increasingly relies on imaging for diagnosis, response assessment, and follow-up. The clinical availability of combined functional/anatomical imaging modalities, which integrate the benefits of visualizing tumor biology with those of high-resolution structural imaging, revolutionized clinical management of oncologic patients. Conventional high-resolution anatomical imaging modalities such as computed tomography (CT) and MRI excel at providing details on lesion location, size, morphology, and structural changes to adjacent tissues; however, these modalities provide little insight into tumor physiology. With the increasing focus on molecularly targeted therapies, imaging radiolabeled compounds with PET and single-photon emission tomography (SPECT) is often carried out to provide insight into a tumor's biological functions and its surrounding microenvironment. Despite their high sensitivity and specificity, PET and SPECT alone are substantially limited by low spatial resolution and inability to provide anatomical detail. Integrating SPECT or PET with a modality capable of providing these (i.e. CT or MR) maximizes their separate strengths and provides anatomical localization of physiological processes with detailed visualization of a tumor's structure. The availability of multimodality (hybrid) imaging with PET/CT, SPECT/CT, and PET/MR improves our ability to characterize lesions and affect treatment decisions and patient management. We have just begun to exploit the truly synergistic capabilities of multimodality imaging. Continued advances in the development of instrumentation and imaging agents will improve our ability to noninvasively characterize disease processes. This review will discuss the evolution of hybrid imaging technology and provide examples of its current and potential future clinical uses. |
| | |
Authors:
|
Stephanie N Histed; Maria L Lindenberg; Esther Mena; Baris Turkbey; Peter L Choyke; Karen A Kurdziel |
Related Documents
:
|
7833164 - Ultrasonography in arthritis of the knee. a comparison with mr imaging. 1929584 - Comparison of clinical, radionuclide, and radiographic features of osteoarthritis of th... 1546334 - Benign osteochondromas and exostotic chondrosarcomas: evaluation of cartilage cap thick... 21071164 - Ultrasonographic evaluation of degenerative changes in the distal radioulnar joint: cor... 8282864 - Postcontrast ct in the diagnosis and assessment of response to thrombolysis in massive ... 9432154 - Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-d... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-5 |
Journal Detail:
|
Title: Nuclear medicine communications Volume: - ISSN: 1473-5628 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multielectron-transfer reactions at single Cu(ii) centers embedded in polyoxotungstates driven by ph...
Next Document: Eye doses to staff in a nuclear medicine department.