Document Detail


Review of functional/anatomical imaging in oncology.
MedLine Citation:
PMID:  22314804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patient management in oncology increasingly relies on imaging for diagnosis, response assessment, and follow-up. The clinical availability of combined functional/anatomical imaging modalities, which integrate the benefits of visualizing tumor biology with those of high-resolution structural imaging, revolutionized clinical management of oncologic patients. Conventional high-resolution anatomical imaging modalities such as computed tomography (CT) and MRI excel at providing details on lesion location, size, morphology, and structural changes to adjacent tissues; however, these modalities provide little insight into tumor physiology. With the increasing focus on molecularly targeted therapies, imaging radiolabeled compounds with PET and single-photon emission tomography (SPECT) is often carried out to provide insight into a tumor's biological functions and its surrounding microenvironment. Despite their high sensitivity and specificity, PET and SPECT alone are substantially limited by low spatial resolution and inability to provide anatomical detail. Integrating SPECT or PET with a modality capable of providing these (i.e. CT or MR) maximizes their separate strengths and provides anatomical localization of physiological processes with detailed visualization of a tumor's structure. The availability of multimodality (hybrid) imaging with PET/CT, SPECT/CT, and PET/MR improves our ability to characterize lesions and affect treatment decisions and patient management. We have just begun to exploit the truly synergistic capabilities of multimodality imaging. Continued advances in the development of instrumentation and imaging agents will improve our ability to noninvasively characterize disease processes. This review will discuss the evolution of hybrid imaging technology and provide examples of its current and potential future clinical uses.
Authors:
Stephanie N Histed; Maria L Lindenberg; Esther Mena; Baris Turkbey; Peter L Choyke; Karen A Kurdziel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  33     ISSN:  1473-5628     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-06     Completed Date:  2012-06-06     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  349-61     Citation Subset:  IM    
Affiliation:
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA.
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MeSH Terms
Descriptor/Qualifier:
Bone Neoplasms / diagnosis
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging / methods*
Neoplasms / diagnosis*
Positron-Emission Tomography / methods*
Radioisotopes / diagnostic use
Radiopharmaceuticals / diagnostic use
Receptors, Somatostatin / radiation effects
Tomography, Emission-Computed, Single-Photon / methods*
Tomography, X-Ray Computed / methods*
Grant Support
ID/Acronym/Agency:
Z99 CA999999/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Radioisotopes; 0/Radiopharmaceuticals; 0/Receptors, Somatostatin
Comments/Corrections

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