Document Detail

Review of functional and anatomical brain connectivity findings in schizophrenia.
MedLine Citation:
PMID:  23324948     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: We review diffusion tensor imaging (DTI) studies that investigate white matter abnormalities in patients with chronic schizophrenia, first episode schizophrenia, and those who are at genetic risk for developing schizophrenia. Additionally, we include studies that combine DTI and functional MRI (fMRI) to investigate brain connectivity abnormalities.
RECENT FINDINGS: Schizophrenia is a complex mental disorder with a peak age of onset in early adulthood. Abnormalities in white matter tracts, which connect brain regions into functional networks, are most likely relevant for understanding structural and functional brain abnormalities in schizophrenia. Dysconnectivity between brain regions, in fact, is thought to underlie cognitive abnormalities in schizophrenia but little is known about how alterations at the functional level relate to abnormalities in anatomical connectivity. DTI has become one of the most popular tools in brain research to address such questions. Here we review white matter abnormalities using DTI with the aim of understanding dysconnectivity of brain regions and their implications in schizophrenia.
SUMMARY: Advances in DTI and in combining DTI with fMRI provide new insight into anatomical and functional connections in the brain, and for studying dysconnectivity in schizophrenia.
Jennifer Fitzsimmons; Marek Kubicki; Martha E Shenton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in psychiatry     Volume:  26     ISSN:  1473-6578     ISO Abbreviation:  Curr Opin Psychiatry     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-09     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  8809880     Medline TA:  Curr Opin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  172-87     Citation Subset:  IM    
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MeSH Terms
Brain Mapping / methods*
Magnetic Resonance Imaging / methods
Neural Pathways / pathology,  physiopathology*
Schizophrenia / pathology,  physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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