Document Detail

Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection.
MedLine Citation:
PMID:  14615709     Owner:  NLM     Status:  MEDLINE    
Respiratory syncytial virus (RSV) infection is the most frequent reason for hospitalization of infants in developed countries. Premature birth without or, especially, with chronic lung disease of prematurity, congenital heart disease, and T-cell immunodeficiency are conditions that predispose to more severe forms of RSV infection. Incomplete development of the airway, damage to the airway, and airway hyperreactivity underlie the increased morbidity of RSV infection in prematurely born infants. Pulmonary hypertension and cyanosis are associated with worse outcomes in infants with congenital heart disease, and prolonged viral replication accounts for more severe illness in immunocompromised individuals.
Robert C Welliver
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  143     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-01-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S112-7     Citation Subset:  AIM; IM    
Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children's Hospital of Buffalo, New York 14222, USA.
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MeSH Terms
Bronchiolitis / pathology,  virology
Child, Preschool
Chronic Disease
Gestational Age
Heart Defects, Congenital / epidemiology
Immunocompromised Host
Infant, Newborn
Infant, Premature
Lung Diseases / pathology,  virology
Respiratory Syncytial Virus Infections / epidemiology*,  immunology,  virology*
Risk Factors
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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