Document Detail


Review of the dioxin problem. Mass spectrometric analyses of tetrachlorodioxins in environmental samples.
MedLine Citation:
PMID:  7013844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Major concern over the chemical group of chlorodioxins has arisen since 2,3,7,8-tetrachlorodibenzo-p-dioxin with its extremely toxic and teratogenic properties has been found in widely distributed pesticides such as the herbicide 2,4,5-trichlorophenoxy acetic acid. Because of its chemical stability and lipophilic nature, 2,3,7,8-tetrachlorodibenzo-p-dioxin released into the environment has the potential of accumulation in the food chain. Mass spectrometry in its various forms has been the method of choice to detect and confirm low parts per billion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Recently, a Consensus Forum held at the National Center for Toxicological Research amongst the various United States Government agencies (Food and Drug Administration, Environmental Protection Agency, US Department of Agriculture and National Institute of Environmental Health Sciences), eloquently demonstrated the potential, as well as the shortcomings, of the various techniques applied. In particular, the availability of a stable 13C labeled 2,3,7,8-tetrachlorodibenzo-p-dioxin has proved to be an essential component to achieve low level quantitation. A brief review of the findings of the Consensus Forum is presented together with a detailed survey of the application of atmospheric pressure ionization mass spectrometry to TCDD analysis at the National Center for Toxicological Research/Food and Drug Administration.
Authors:
T Cairns; L Fishbein; R K Mitchum
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biomedical mass spectrometry     Volume:  7     ISSN:  0306-042X     ISO Abbreviation:  Biomed. Mass Spectrom.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-07-23     Completed Date:  1981-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0430246     Medline TA:  Biomed Mass Spectrom     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  484-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atmospheric Pressure
Carcinogens
Dioxins / analysis*,  metabolism,  toxicity
Drug Stability
Guinea Pigs
Humans
Intestinal Absorption
Male
Mass Spectrometry
Mutagens
Rats
Teratogens
Tissue Distribution
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Dioxins; 0/Mutagens; 0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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