Document Detail


Review of dilated cardiomyopathies. Dilated cardiomyopathies and altered prothrombotic state: a point of view of the literature.
MedLine Citation:
PMID:  16462724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure is an enormously important clinical problem that, if not faced, may overwhelm health care resources. Primary and secondary cardiomyopathies cause the majority of cases of clinical heart failure, which is thus better approached from the utility point of view of myocardial failure. Furthermore, the risk of thromboembolic complications presenting in such disease may be higher than in ischemic cardiomyopathy. Intracardiac thrombi and mural endocardial plaques (from the organization of thrombi) are present at necropsy in more than 50% of patients with dilated cardiomyopathy (DCM). Several studies have shown that systemic and pulmonary emboli are more frequent in patients with ventricular thrombi or plaques. Dilated cardiomyopathy has been associated with left ventricular thrombosis which leads to substantial morbidity and mortality as a site for peripheral emboli. There are some studies on patients with dilated cardiomyopathy showing altered hemostasis and platelet behavior despite sinus rhythm. Platelet activation, thrombin activation and fibrinolytic activity are increased in patients with DCM compared to normal subjects. However, these markers reflecting coagulation activation in patients with left ventricle thrombus are comparable to those in patients without thrombus in the left ventricle. The pathophysiology and clinical issues concerning the susceptibility to develop left ventricular (LV) thrombosis and its complications like cerebrovascular disease in patients with DCM are summarized and the most recent articles present in the medical literature are reviewed.
Authors:
M Mazzone; M La Sala; G Portale; S Ursella; P Forte; L Carbone; A Testa; G Pignataro; M Covino; N Gentiloni Silveri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Panminerva medica     Volume:  47     ISSN:  0031-0808     ISO Abbreviation:  Panminerva Med     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421110     Medline TA:  Panminerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  157-67     Citation Subset:  IM    
Affiliation:
Department of Emergency and Admission, Sacro Cuore Catholic University A. Gemelli, Polyclinic, Rome, Italy. marinellamazzone@yahoo.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / classification
Cardiomyopathy, Dilated / blood,  complications,  physiopathology*,  therapy
Heart Failure / etiology,  physiopathology
Hemostasis
Humans
Prognosis
Thrombosis / etiology*

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