Document Detail

Review of current therapies for secondary hypertrophic pulmonary osteoarthropathy.
MedLine Citation:
PMID:  20936419     Owner:  NLM     Status:  MEDLINE    
Hypertrophic osteoarthropathy (HOA) is a disabling condition that may occur secondarily to primary lung cancer. It is characterized by digital clubbing, arthralgia/arthritis, and periostosis of the tubular bones. The pain associated with HOA can be disabling and often refractory to conventional analgesics. We performed a comprehensive review of the literature using the PubMed database on treatment modalities available for HOA. We found 52 relevant articles-40 case reports, six case series, two review papers, and four combined case series and review papers. There were no randomized controlled trials reported. We then classified treatments used for HOA into two categories: (1) treatment of primary cause (i.e., resection of tumor, chemotherapy, radiotherapy, treatment of infection, etc.) and (2) symptomatic treatments (i.e., bisphosphonates, octreotide, NSAIDs, vagotomy, etc.). Subsequently, we summarized the main findings for each treatment. Although the clinical diagnosis of HOA has existed for over 100 years, the pathogenesis mechanism has not yet been elucidated, and treatment options for this condition remain experimental. Primary treatment is the most widely reported modality to be efficacious. In cases which primary therapy is not possible, several symptomatic treatment modalities are suggested, with various degree of success. Further research is needed to clarify the pathophysiological mechanism of HOA as to appropriately direct therapy.
Sheila Nguyen; Mehrnaz Hojjati
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-09
Journal Detail:
Title:  Clinical rheumatology     Volume:  30     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-06     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  7-13     Citation Subset:  IM    
University of Minnesota Medical School, Minneapolis, MN, USA.
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MeSH Terms
Antineoplastic Agents / pharmacology
Diphosphonates / chemistry
Lung Neoplasms / complications*
Middle Aged
Octreotide / pharmacology
Osteoarthropathy, Secondary Hypertrophic / complications,  therapy*
Quinazolines / pharmacology
Rheumatology / methods*
Treatment Outcome
Vagotomy / methods
Reg. No./Substance:
0/Antineoplastic Agents; 0/Diphosphonates; 0/Quinazolines; 83150-76-9/Octreotide; S65743JHBS/gefitinib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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