Document Detail

Review of current theories for abdominal aortic aneurysm pathogenesis.
MedLine Citation:
PMID:  19769804     Owner:  NLM     Status:  MEDLINE    
Atherosclerotic plaques are a feature of abdominal aortic aneurysms (AAAs). Atherosclerosis and AAA appear to share similar risk factors. These observations have led to the conclusion that AAAs are a consequence of advanced atherosclerosis.This review explores current theories regarding the pathogenesis of AAA and their implications for treatment.A systematic literature search was conducted using the search terms abdominal aortic aneurysm, atherosclerosis, pathogenesis, and systemic disease. Articles were categorized according to the association of AAAs with atherosclerosis, arteriomegaly, peripheral aneurysm, systemic expression, genetics, autoimmunity, oxidative stress, and systemic disease. Twenty-nine articles reporting changes in the systemic vasculature associated with AAA and 12 articles examining the shared risk factor hypothesis were identified.There is insufficient evidence to confirm that AAAs are the result of advanced atherosclerosis. The bulk of evidence points to AAA disease being a systemic disease of the vasculature, with a predetermined genetic susceptibility leading to a phenotype governed by environmental factors.
Ian M Nordon; Robert J Hinchliffe; Peter J Holt; Ian M Loftus; Matthew M Thompson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vascular     Volume:  17     ISSN:  1708-5381     ISO Abbreviation:  Vascular     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-09-22     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196722     Medline TA:  Vascular     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  253-63     Citation Subset:  IM    
St George's Vascular Institute, St James' Wing, St George's Hospital, London, UK.
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MeSH Terms
Aortic Aneurysm, Abdominal / etiology*,  pathology,  therapy
Atherosclerosis / complications
Dilatation, Pathologic / complications
Genetic Predisposition to Disease
Oxidative Stress
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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