| Review of current theories for abdominal aortic aneurysm pathogenesis. | |
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MedLine Citation:
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PMID: 19769804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerotic plaques are a feature of abdominal aortic aneurysms (AAAs). Atherosclerosis and AAA appear to share similar risk factors. These observations have led to the conclusion that AAAs are a consequence of advanced atherosclerosis.This review explores current theories regarding the pathogenesis of AAA and their implications for treatment.A systematic literature search was conducted using the search terms abdominal aortic aneurysm, atherosclerosis, pathogenesis, and systemic disease. Articles were categorized according to the association of AAAs with atherosclerosis, arteriomegaly, peripheral aneurysm, systemic expression, genetics, autoimmunity, oxidative stress, and systemic disease. Twenty-nine articles reporting changes in the systemic vasculature associated with AAA and 12 articles examining the shared risk factor hypothesis were identified.There is insufficient evidence to confirm that AAAs are the result of advanced atherosclerosis. The bulk of evidence points to AAA disease being a systemic disease of the vasculature, with a predetermined genetic susceptibility leading to a phenotype governed by environmental factors. |
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Authors:
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Ian M Nordon; Robert J Hinchliffe; Peter J Holt; Ian M Loftus; Matthew M Thompson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Vascular Volume: 17 ISSN: 1708-5381 ISO Abbreviation: Vascular Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-09-22 Completed Date: 2009-11-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196722 Medline TA: Vascular Country: Canada |
Other Details:
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Languages: eng Pagination: 253-63 Citation Subset: IM |
Affiliation:
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St George's Vascular Institute, St James' Wing, St George's Hospital, London, UK. inordon@sgul.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aortic Aneurysm, Abdominal
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etiology*,
pathology,
therapy Atherosclerosis / complications Autoimmunity Dilatation, Pathologic / complications Female Genetic Predisposition to Disease Humans Male Oxidative Stress Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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