Document Detail

Review of clinical presentations in Thai patients with primary amoebic meningoencephalitis.
MedLine Citation:
PMID:  15208515     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Primary amoebic meningoencephalitis (PAM) is a very rare but deadly infection of the central nervous system. Since the disease was first identified in 1965, fewer than 200 cases have been observed worldwide.
OBJECTIVE: The author performed a literature review of the reports of PAM in Thailand in order to study the clinical summary of PAM among Thai patients.
DESIGN: This study was designed as a descriptive retrospective study. A literature review of the papers concerning PAM in Thailand was performed.
RESULTS: According to this study, there have been at least 12 reports of PAM in Thailand, of which 2 cases were nonlethal. The mean age was 15.2 +/- 16.1 years with a male:female ratio of about 2:1. History of risk behaviors such as suffocation of surface water during swimming was demonstrated in 6 cases. Also, 2 interesting cases involved possible water contact according to the Thai tradition and culture. Concerning the patients' clinical features, fever, headache, impaired consciousness, and stiff neck were seen in all cases. However, some unusual presentations such as intermittent abdominal pain and convulsion were also seen in this series. Similar to worldwide findings, most cases occurred during the summer months. Most of the cases involved young males from rural provinces in various regions of Thailand. Concerning the laboratory investigation, the cerebrospinal fluid (CSF) profile presented the polymorphonuclear (PMN) pleomorphic with hypoglycorhachia pattern. Trophozoite could be identified in all but 2 cases in this series.
CONCLUSION: PAM is sporadically reported in Thailand but remains a public health issue. The clinical diagnosis of PAM is usually difficult as many clinicians are unfamiliar with the disease. The prognosis outcome is usually grave although broad medications are prescribed.
Viroj Wiwanitkit
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2004-03-08
Journal Detail:
Title:  MedGenMed : Medscape general medicine     Volume:  6     ISSN:  1531-0132     ISO Abbreviation:  MedGenMed     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-21     Completed Date:  2006-05-18     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  100894134     Medline TA:  MedGenMed     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2     Citation Subset:  IM    
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
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MeSH Terms
Amebiasis / diagnosis*,  mortality*,  parasitology
Central Nervous System Protozoal Infections / diagnosis*,  mortality*,  parasitology
Meningoencephalitis / diagnosis*,  mortality*,  parasitology
Naegleria fowleri / isolation & purification*
Periodicals as Topic / statistics & numerical data
Retrospective Studies
Risk Assessment / methods
Risk Factors
Thailand / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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