| Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. | |
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MedLine Citation:
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PMID: 6346907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On the basis of early reports suggesting that doxepin has fewer cardiovascular effects than do other tricyclic antidepressants, doxepin continues to be recommended for the treatment of depression in cardiac patients and in the elderly. However, these reports have been criticized, and other evidence has suggested opposite conclusions. To clarify this issue, the author reviewed clinical and animal studies and found that, in general, doxepin has an effect comparable to the effects of other tricyclic antidepressants on cardiac conduction, cardiac rhythm, heart rate, blood pressure, and cardiac mechanics. |
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Authors:
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D J Luchins |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: The American journal of psychiatry Volume: 140 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-08-26 Completed Date: 1983-08-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1006-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antidepressive Agents, Tricyclic / adverse effects, pharmacology* Arrhythmias, Cardiac / chemically induced Blood Pressure / drug effects Cardiovascular System / drug effects* Depressive Disorder / complications, drug therapy Dogs Doxepin / adverse effects, pharmacology* Electrocardiography Heart Conduction System / drug effects Heart Diseases / complications Heart Rate / drug effects Humans Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 1668-19-5/Doxepin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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