| Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding. | |
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MedLine Citation:
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PMID: 15335392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastro-oesophageal variceal bleeding is the last step in a chain of events that starts with an increased portal pressure, and is followed by the formation and progressive dilatation of gastro-oesophageal varices. When the tension of the thin wall of the varices exceeds its elastic limit, the varices rupture and bleed. Wall tension is directly proportional to variceal pressure (which is a function of portal pressure) and variceal radius, and inversely related to the thickness of the variceal wall. The above facts explain why a high portal pressure (usually determined by the hepatic venous pressure gradient, or HVPG) and the presence at endoscopy of large varices with red wheals, red spots or diffuse redness on the varices (signalling a reduced wall thickness) correlate with the risk of bleeding. |
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Authors:
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A Dell'era; J Bosch |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 20 Suppl 3 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-31 Completed Date: 2004-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 8-15; discussion 16-7 Citation Subset: IM |
Affiliation:
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Liver Unit, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, University of Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
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complications Blood Coagulation Disorders / complications Blood Transfusion / methods Esophageal and Gastric Varices / etiology*, physiopathology Gastrointestinal Hemorrhage / etiology*, physiopathology, therapy Humans Hypertension, Portal / complications*, physiopathology Liver Failure / complications Portal Pressure / physiology* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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