Document Detail

Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding.
MedLine Citation:
PMID:  15335392     Owner:  NLM     Status:  MEDLINE    
Gastro-oesophageal variceal bleeding is the last step in a chain of events that starts with an increased portal pressure, and is followed by the formation and progressive dilatation of gastro-oesophageal varices. When the tension of the thin wall of the varices exceeds its elastic limit, the varices rupture and bleed. Wall tension is directly proportional to variceal pressure (which is a function of portal pressure) and variceal radius, and inversely related to the thickness of the variceal wall. The above facts explain why a high portal pressure (usually determined by the hepatic venous pressure gradient, or HVPG) and the presence at endoscopy of large varices with red wheals, red spots or diffuse redness on the varices (signalling a reduced wall thickness) correlate with the risk of bleeding.
A Dell'era; J Bosch
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  20 Suppl 3     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-31     Completed Date:  2004-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  8-15; discussion 16-7     Citation Subset:  IM    
Liver Unit, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, University of Barcelona, Spain.
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MeSH Terms
Bacterial Infections / complications
Blood Coagulation Disorders / complications
Blood Transfusion / methods
Esophageal and Gastric Varices / etiology*,  physiopathology
Gastrointestinal Hemorrhage / etiology*,  physiopathology,  therapy
Hypertension, Portal / complications*,  physiopathology
Liver Failure / complications
Portal Pressure / physiology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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