| Review article: pharmacology of esomeprazole and comparisons with omeprazole. | |
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MedLine Citation:
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PMID: 12614299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma concentration measurements have confirmed that the advantageous hepatic metabolism of esomeprazole results in a greater delivery of acid suppressant to the systemic circulation, compared with an equal dose of omeprazole. Also, this superior delivery has been shown to cause a more consistent and greater suppression of pentagastrin-stimulated gastric acid secretion by esomeprazole, 20 mg, compared with omeprazole, 20 mg. The superior acid-suppressant properties of esomeprazole have been revealed by extensive 24-h intragastric pH-monitoring studies. Compared with omeprazole, 20 mg, esomeprazole, 20 mg and 40 mg, has been shown to give superior outcomes on three key measures of antisecretory effect: (1) consistency amongst individuals; (2) duration over the 24-h cycle; (3) overall impact on pH. As there is a substantial increment of acid control from esomeprazole, 20 mg, to esomeprazole, 40 mg, this latter dose is the most appropriate to investigate for modern initial therapy of reflux disease, with the aim of achieving the highest possible response rates in the shortest possible time. |
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Authors:
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J Dent |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 17 Suppl 1 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-03-04 Completed Date: 2003-04-07 Revised Date: 2013-01-07 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia. jdent@mail.rah.sa.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Ulcer Agents
/
administration & dosage,
blood,
pharmacology* Esomeprazole Sodium Gastric Acid / secretion Gastroesophageal Reflux / drug therapy* Humans Hydrogen-Ion Concentration Omeprazole / administration & dosage, blood, pharmacology* Pentagastrin / pharmacology Proton Pumps / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Proton Pumps; 5534-95-2/Pentagastrin; 73590-58-6/Omeprazole; L2C9GWQ43H/Esomeprazole Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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