Document Detail


Review article: the pathogenesis and management of eosinophilic oesophagitis.
MedLine Citation:
PMID:  16842447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Eosinophilic oesophagitis is a clinicopathological disease affecting both children and adults that is characterized by symptoms of gastro-oesophageal reflux disease (feeding refusal, vomiting, heartburn, dysphagia and food impaction) and dense oesophageal eosinophilia both of which are unresponsive to proton pump inhibition. AIM: To present a review of the recent literature examining the pathogenesis and treatments of eosinophilic oesophagitis. METHODS: We performed a PubMed search for eosinophilic oesophagitis, pathogenesis and treatments. RESULTS: Translational and basic studies suggest that this disease is sparked by food or by aeroallergens. To date, effective treatments include systemic/topical corticosteroids, specific food elimination or an elemental diet. While several studies identified oesophageal strictures as potential complications of unbridled eosinophilia, the natural history of the disease is still not certain. Recent studies suggest a role for interleukin-5 and eotaxin-3 in the pathogenesis of eosinophilic oesophagitis and suggest an impact of future targeted therapeutic agents. CONCLUSIONS: Eosinophilic oesophagitis represents a immune-mediated disease of undetermined pathogenesis. While many patients develop clinicopathological findings following ingestion of foods, others do not. Natural history studies will be critical to defining future treatment paradigms.
Authors:
G T Furuta; A Straumann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  24     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-17     Completed Date:  2007-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-82     Citation Subset:  IM    
Affiliation:
Gastroenterology Division, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. glenn.furuta@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Cycle
Child
Cytokines / metabolism
Endoscopy, Gastrointestinal / methods
Eosinophilia* / etiology,  pathology,  therapy
Eosinophils / pathology
Esophagitis* / etiology,  pathology,  therapy
Humans
Intestinal Mucosa
Nutritional Support
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections
Comment In:
Aliment Pharmacol Ther. 2006 Oct 15;24(8):1264-7   [PMID:  17014589 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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