| Review article: pancreatic renin-angiotensin systems in health and disease. | |
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MedLine Citation:
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PMID: 21851372 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background In addition to the circulating (endocrine) renin-angiotensin system (RAS), local renin-angiotensin systems are now known to exist in diverse cells and tissues. Amongst these, pancreatic renin-angiotensin systems have recently been identified and may play roles in the physiological regulation of pancreatic function, as well as being implicated in the pathogenesis of pancreatic diseases including diabetes, pancreatitis and pancreatic cancer. Aim To review and summarise current knowledge of pancreatic renin-angiotensin systems. Methods We performed an extensive PubMed, Medline and online review of all relevant literature. Results Pancreatic RAS appear to play various roles in the regulation of pancreatic physiology and pathophysiology. Ang II may play a role in the development of pancreatic ductal adenocarcinoma, via stimulation of angiogenesis and prevention of chemotherapy toxicity, as well as in the initiation and propagation of acute pancreatitis (AP); whereas, RAS antagonism is capable of preventing new-onset diabetes and improving glycaemic control in diabetic patients. Current evidence for the roles of pancreatic RAS is largely based upon cell and animal models, whilst definitive evidence from human studies remains lacking. Conclusions The therapeutic potential for RAS antagonism, using cheap and widely available agents, and may be untapped and such roles are worthy of active investigation in diverse pancreatic disease states. |
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Authors:
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J R A Skipworth; G Szabadkai; S W M Olde Damink; P S Leung; S E Humphries; H E Montgomery |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: - ISSN: 1365-2036 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Surgery and Interventional Science, UCL, London, UK. Department of Hepatopancreaticobiliary Surgery, Royal Free Hospital, London, UK. Department of Cell and Developmental Biology, UCL, London, UK. Department of Surgery, Maastricht University Medical Centre, Maastricht, Netherlands. School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China. Centre for Cardiovascular Genetics & UCL Genetics Institute, UCL, London, UK. Institute of Human Health and Performance, UCL, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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