Document Detail


Review article: olestra and its gastrointestinal safety.
MedLine Citation:
PMID:  9882026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Olestra is a fat substitute made from sucrose and vegetable oil. Olestra is neither digested nor absorbed, and therefore adds no calories or fat to the diet. Because the gut is the only organ that is exposed to olestra, the potential for olestra to affect gastrointestinal structure and function, and the absorption of nutrients from the gut, has been investigated. Histological evaluations performed after long-term feeding studies have shown no indications that olestra causes injury to the gastrointestinal mucosa. Olestra is not metabolized by the colonic microflora, and has no meaningful effects on the metabolic function of these organisms. Studies of gastrointestinal transit have shown that the consumption of olestra with food does not affect gastric emptying, or small or large bowel transit times. Olestra does not affect the absorption of macronutrients, water-soluble vitamins or minerals. It causes a dose-responsive decrease in the availability of the fat-soluble vitamins A, D, E and K; however, this potentially adverse effect is offset by the addition of vitamins to olestra-containing foods. Olestra has no consistent effect on the amount of total bile acids excreted in the faeces, and therefore probably has no significant effect on bile acid absorption. The occurrence of gastrointestinal symptoms, including diarrhoea, loose stools, gas and abdominal cramping, after consumption of olestra under ordinary snacking conditions is comparable to that following consumption of triglyceride-containing snacks.
Authors:
A B Thomson; R H Hunt; N L Zorich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  12     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1185-200     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, University of Alberta, Edmonton, Canada. alan.thomson@ualberta.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Avitaminosis / chemically induced
Biological Availability
Digestive System / drug effects*
Dose-Response Relationship, Drug
Fat Substitutes / adverse effects*,  pharmacokinetics
Fatty Acids / adverse effects*,  pharmacokinetics
Food-Drug Interactions
Humans
Sucrose / adverse effects,  analogs & derivatives*,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Fat Substitutes; 0/Fatty Acids; 121854-29-3/sucrose polyester; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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