Document Detail

Review article: the modern management of portal vein thrombosis.
MedLine Citation:
PMID:  19678814     Owner:  NLM     Status:  In-Process    
BACKGROUND: Portal vein thrombosis (PVT) is an important cause of portal hypertension. It may occur as such with or without associated cirrhosis and hepatocellular carcinoma. Information on its management is scanty. AIM: To provide an update on the modern management of portal vein thrombosis. Information on portal vein thrombosis in patients with and without cirrhosis and hepatocellular carcinoma is also updated. METHODS: A pubmed search was performed to identify the literature using search items portal vein thrombosis-aetiology and treatment and portal vein thrombosis in cirrhosis and hepatocellular carcinoma. RESULTS: Portal vein thrombosis occurs because of local inflammatory conditions in the abdomen and prothrombotic factors. Acute portal vein thrombosis is usually symptomatic when associated with cirrhosis and/or superior mesenteric vein thrombosis. Anticoagulation should be given for 3-6 months if detected early. If prothrombotic factors are identified, anticoagulation should be given lifelong. Chronic portal vein thrombosis usually presents with well tolerated upper gastrointestinal bleed. It is diagnosed by imaging, which demonstrates a portal cavernoma in place of a portal vein. Anticoagulation does not have a definite role, but bleeds can be treated with endotherapy or shunt surgery. Rarely liver transplantation may be considered. CONCLUSION: Role of anticoagulation in chronic portal vein thrombosis needs to be further studied.
Y Chawla; A Duseja; R K Dhiman
Related Documents :
20565694 - Cardiopulmonary manifestations of portovenous shunts from congenital absence of the por...
1661674 - Computed tomography during arterial portography prior to transcatheter arterial therapy...
15549434 - Portal and mesenteric vein thrombosis after portal vein embolization in a patient with ...
7548394 - Vascular pattern of a metastatic liver tumor in a dog:--a scanning electron microscopic...
7056114 - Cyanosis following right pneumonectomy: importance of patent foramen ovale.
6976154 - Transmural gradient in high-energy phosphate content in patients with coronary artery d...
Publication Detail:
Type:  Journal Article     Date:  2009-08-12
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  30     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  881-94     Citation Subset:  IM    
Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical trial: ulcerative colitis maintenance treatment with 5-ASA: a 1-year, randomized multicentr...
Next Document:  DNA content in the diagnostic biopsy for benign-adjacent and cancer-tissue areas predicts the need f...