| Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases. | |
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MedLine Citation:
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PMID: 10468672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ursodeoxycholic acid (ursodiol) is a non-toxic, hydrophilic bile acid used to treat predominantly cholestatic liver disorders. Better understanding of the cellular and molecular mechanisms of action of ursodeoxycholic acid has helped to elucidate its cytoprotective, anti-apoptotic, immunomodulatory and choleretic effects. Ursodeoxycholic acid prolongs survival in primary biliary cirrhosis and it improves biochemical parameters of cholestasis in various other cholestatic disorders including primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, cystic fibrosis and total parenteral nutrition-induced cholestasis. However, a positive effect on survival remains to be established in these diseases. Ursodeoxycholic acid is of unproven efficacy in non-cholestatic disorders such as acute rejection after liver transplantation, non-alcoholic steatohepatitis, alcoholic liver disease and chronic viral hepatitis. This review outlines the present knowledge of the modes of action of ursodeoxycholic acid, and presents data from clinical trials on its use in chronic liver diseases. |
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Authors:
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M Trauner; I W Graziadei |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 13 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-10-07 Completed Date: 1999-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 979-96 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Graz, Austria. michael.trauner@kfunigraz.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholagogues and Choleretics / pharmacology, therapeutic use* Cholestasis, Intrahepatic / drug therapy Chronic Disease Female Humans Liver Diseases / drug therapy* Pregnancy Ursodeoxycholic Acid / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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