Document Detail

Review article: hepatobiliary complications associated with total parenteral nutrition.
MedLine Citation:
PMID:  10903005     Owner:  NLM     Status:  MEDLINE    
Parenteral nutrition is often associated with hepatobiliary complications. Hepatic steatosis, intrahepatic cholestasis and biliary sludge are the most frequent. Cholestasis predominates in infants, steatosis in adults, and biliary sludge in both. Other less frequent complications are steatohepatitis and gallstones. All hepatobiliary complications are more likely to occur after extended periods of total parenteral nutrition, and are prevented by the concomitant consumption of nutrients by the enteral route. The pathogenic causes are multiple and only partially known. They include lack of gastrointestinal stimuli for biliary secretion and gall-bladder motility, abnormalities in bile acid metabolism, the presence of sepsis, and the potentially unfavourable effects of individual components in the total parenteral nutrition formulae, including an excess of calories. Each potential mechanism and its clinical relevance is discussed in this review.
M Angelico; P Della Guardia
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  14 Suppl 2     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-11-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Dipartimento di Sanità Publica, University of Rome Tor Vergata, and IRCCS Santa Lucia, Rome, Italy.
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MeSH Terms
Cholelithiasis / etiology*
Cholestasis, Intrahepatic / etiology*
Gastrointestinal Motility*
Infant, Newborn
Parenteral Nutrition, Total / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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