Document Detail

Review article: gastro-oesophageal reflux disease as a functional gastrointestinal disorder.
MedLine Citation:
PMID:  15521855     Owner:  NLM     Status:  MEDLINE    
Gastro-oesophageal reflux disease encompasses a family of disorders united by a common pathogenesis: the excessive reflux of gastric contents. The best defined disorder is oesophagitis, but it is now evident that proton pump inhibitor therapy can resolve oesophagitis in virtually every case. The same cannot be said for gastro-oesophageal reflux disease symptoms, however, thus moving the frontier to symptom control. Endoscopy-negative reflux disease is a heterogeneous group, no longer bound by the common denominator of endoscopic findings. In fact, three distinct patient subgroups emerge: (i) individuals who in essence have oesophagitis, but are either in remission or simply fail to meet the endoscopic criteria; (ii) patients with hypersensitivity to oesophageal stimuli; and (iii) patients with 'functional heartburn' whose symptoms are not related to reflux. Given this heterogeneity, it is not surprising that the efficacy of antisecretory drugs is less impressive. This has led to new therapeutic approaches beyond acid control: mucosal protective agents, either central nervous system or peripherally acting compounds aimed at normalizing hyperalgesia, and reflux inhibitors and serotonergic agents, such as tegaserod.
P J Kahrilas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  20 Suppl 7     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-04-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Northwestern University, Feinberg School of Medicine, Department of Medicine, Division of Gastroenterology, Chicago, IL 60611-2951, USA.
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MeSH Terms
Antacids / therapeutic use
Antidepressive Agents, Tricyclic / therapeutic use
Esophagitis / etiology
GABA Agonists / therapeutic use
Gastroesophageal Reflux / drug therapy*,  etiology
Serotonin Agonists / therapeutic use
Reg. No./Substance:
0/Antacids; 0/Antidepressive Agents, Tricyclic; 0/GABA Agonists; 0/Serotonin Agonists

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