Document Detail

Review article: gastrin releasing peptide and its value in assessing gastric secretory function.
MedLine Citation:
PMID:  8527610     Owner:  NLM     Status:  MEDLINE    
Gastrin releasing peptide (GRP) has proved to be a particularly valuable tool in detecting disturbances of gastric secretory function associated with duodenal ulcer disease and Helicobacter pylori infection, and it has furthered understanding of the pathophysiology of these conditions. Its attractiveness lies in the fact that it simultaneously activates many physiological control processes, both stimulatory and inhibitory. This facilitates the detection of a defect in any of the many controls involved in regulating biological function. Other gastrointestinal functions such as gall-bladder contraction, pancreatic secretion and gastrooesophageal motility are also subject to complex regulatory controls, and GRP may also be of value in investigating disturbances of these processes.
K E McColl; E el-Omar
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  9     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-29     Completed Date:  1996-01-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
University Department of Medicine & Therapeutics, Western Infirmary, Glasgow, UK.
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MeSH Terms
Duodenal Ulcer / diagnosis
Gastric Acid / secretion
Gastrins / metabolism*,  physiology*
Helicobacter pylori
Peptic Ulcer / diagnosis*
Peptides / physiology*
Receptors, Bombesin / drug effects*
Reg. No./Substance:
0/Gastrins; 0/Peptides; 0/Receptors, Bombesin

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