Document Detail

Review article: epidemiology of gall-bladder disease--role of intestinal transit.
MedLine Citation:
PMID:  10902996     Owner:  NLM     Status:  MEDLINE    
Recent epidemiological studies have suggested that hyperinsulinaemia may be a central factor in the pathogenesis of cholesterol gallstones, explaining a probable link with physical inactivity as well as abdominal adiposity. There is also increasing evidence for the hypothesis that enrichment of bile with DCA. 'the colonic bile acid', leads to enrichment of bile with cholesterol. Biliary DCA can be raised and lowered by slowing down and speeding up colonic transit, respectively. Slow transit is characteristic of non-obese British women with gallstones and of non-obese peasants in a gallstone-prone mountain community. High biliary DCA predicts recurrence of gallstones and so does laxative usage, a pointer to constipation and therefore to slow transit. In some studies, at least, a high fibre intake is protective against gallstones. Much else besides fibre influences colonic function. Future studies of gallstone aetiology should include measurements of colonic function. Measures that speed up colonic transit should be tested for their ability to prevent gallstone formation in high-risk individuals.
K W Heaton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  14 Suppl 2     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-11-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
University of Bristol, Bristol Royal Infirmary, UK.
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MeSH Terms
Body Mass Index
Cholelithiasis / epidemiology,  etiology*,  physiopathology
Deoxycholic Acid / pharmacology
Epidemiologic Studies
Gastrointestinal Transit*
Obesity / physiopathology
Risk Factors
Reg. No./Substance:
83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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