| Review article: a drug therapy for the prevention of variceal haemorrhage. | |
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MedLine Citation:
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PMID: 11207505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of varices is a major complication of cirrhosis, and variceal haemorrhage has a high mortality. There have been major advances in the primary and secondary prevention of variceal haemorrhage over the last 20 years involving endoscopic, radiological and pharmacological approaches. This review concentrates principally on drug therapy, particularly on the numerous haemodynamic studies. Many of these drugs have not been studied in clinical trials, but provide data about the underlying pathogenesis of portal hypertension. Also covered in this review are the randomized controlled trials and meta-analyses that involve a large number of patients. These trials involve relatively few drugs such as non-selective beta-blockers and nitrates. Correlations between haemodynamic and clinical parameters are discussed. Despite the recent increase in the use of alternative endoscopic therapies, an effective and well tolerated drug remains a clinically important research goal. |
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Authors:
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D Tripathi; P C Hayes |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 15 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-21 Completed Date: 2001-05-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 291-310 Citation Subset: IM |
Affiliation:
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Liver Unit, Department of Medicine, Royal Infirmary, Edinburgh, UK. d.tripathi@ed.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Hemodynamics Hemorrhage / etiology, prevention & control Humans Hypertension, Portal / complications, drug therapy* Liver / blood supply* Liver Cirrhosis / complications* Randomized Controlled Trials as Topic Varicose Veins / drug therapy*, etiology, prevention & control |
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