Document Detail

Review article: the development of atrophic gastritis--Helicobacter pylori and the effects of acid suppressive therapy.
MedLine Citation:
PMID:  8527609     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori is uniquely adapted to survival in the strongly acidic gastric lumen. In vitro, both acid and certain acid suppressors affect bacterial growth. In vivo, there is little evidence that acid suppressors have any effect on bacterial survival. In contrast, decrease of acid secretion quickly leads to a spreading of the bacterial infection throughout the body and fundus of the stomach, which is accompanied by an increase of the associated gastritis. Helicobacter pylori gastritis may, in a substantial number of infected subjects, ultimately lead to atrophy and intestinal metaplasia, conditions with an increased risk for gastric cancer. This review summarizes the data on the interrelation between Helicobacter pylori, gastric acid secretion and development of atrophic gastritis.
E J Kuipers; A Lee; E C Klinkenberg-Knol; S G Meuwissen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  9     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-29     Completed Date:  1996-01-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  331-40     Citation Subset:  IM    
Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Anti-Ulcer Agents / adverse effects,  pharmacology,  therapeutic use*
Follow-Up Studies
Gastric Juice / secretion
Gastritis, Atrophic / epidemiology*,  etiology*
Helicobacter Infections / complications*,  drug therapy
Helicobacter pylori* / drug effects
Omeprazole / adverse effects,  therapeutic use
Secretory Rate / drug effects
Vagotomy / adverse effects
Reg. No./Substance:
0/Anti-Ulcer Agents; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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