Document Detail

Review article: Acute serious and fatal reactions to contrast media: our current understanding.
MedLine Citation:
PMID:  16046418     Owner:  NLM     Status:  MEDLINE    
Serious or fatal reactions to a contrast medium (CM) are unpredictable but fortunately rare. History of serious reaction to CM, bronchial asthma or multiple allergies increases the incidence of serious reactions by a factor of 5. Serious or fatal reaction to CM could be due to direct effect on basophils and mast cells or IgE mediated (type 1 hypersensitivity reaction). Activation of the kinin system leading to the formation of bradykinin could also be involved. Complement activation is unlikely to be a primary factor in initiating a serious reaction to CM. Avoiding CM administration in patients at high risk of serious reaction is advisable, but if the administration is deemed essential all precautions should be implemented and measures to treat serious reactions should be readily available. Oxygen supplementation, intravenous administration of physiological fluids and intramuscular injection of 0.5 ml adrenalin (1:1000) should be considered in the first line management of acute anaphylaxis. The ability to assess and treat serious CM reaction effectively is an essential skill that the radiologist should have and maintain.
S K Morcos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of radiology     Volume:  78     ISSN:  0007-1285     ISO Abbreviation:  Br J Radiol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-27     Completed Date:  2005-09-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  686-93     Citation Subset:  AIM; IM    
Department of Diagnostic Imaging, Northern General Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield S5 7AU, UK.
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MeSH Terms
Acute Disease
Anaphylaxis / chemically induced*,  immunology,  prevention & control,  therapy
Basophils / immunology
Complement Activation / immunology
Contrast Media / administration & dosage,  adverse effects*
Hypersensitivity, Immediate / chemically induced*,  prevention & control,  therapy
Kinins / immunology
Mast Cells / immunology
Oxygen / administration & dosage
Radiography / adverse effects*
Risk Factors
Reg. No./Substance:
0/Contrast Media; 0/Kinins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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