Document Detail


Review of approaches to the recording of background lesions in toxicological pathology studies in rats.
MedLine Citation:
PMID:  24960062     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pathological evaluation of lesions caused directly by treatment must always take into account the recognition of background (incidental) findings. Background lesions can be congenital or hereditary, histological variations such as differences in the normal morphology of various organs in various animal species and normal cyclicity of reproductive organs, changes related to trauma or normal aging and physiologic or hormonal changes. This review focuses on the importance of background changes and the correct approach to the recording thereof. The review includes discussion on sources of variability in background changes, the correct use of terminology, the concept of thresholds, historical control data, diagnostic drift, blind reading of slides, scoring and artifacts. The review is illustrated with background lesions in Sprague Dawley and Wistar rats.
Authors:
Ef McInnes; Cl Scudamore
Publication Detail:
Type:  REVIEW     Date:  2014-6-21
Journal Detail:
Title:  Toxicology letters     Volume:  -     ISSN:  1879-3169     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ireland Ltd.
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