Document Detail

Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study.
MedLine Citation:
PMID:  10736382     Owner:  NLM     Status:  MEDLINE    
Monosodium glutamate (MSG) has a long history of use in foods as a flavor enhancer. In the United States, the Food and Drug Administration has classified MSG as generally recognized as safe (GRAS). Nevertheless, there is an ongoing debate exists concerning whether MSG causes any of the alleged reactions. A complex of symptoms after ingestion of a Chinese meal was first described in 1968. MSG was suggested to trigger these symptoms, which were referred to collectively as Chinese Restaurant Syndrome. Numerous reports, most of them anecdotal, were published after the original observation. Since then, clinical studies have been performed by many groups, with varying degrees of rigor in experimental design ranging from uncontrolled open challenges to double-blind, placebo controlled (DBPC) studies. Challenges in subjects who reported adverse reactions to MSG have included relatively few subjects and have failed to show significant reactions to MSG. Results of surveys and of clinical challenges with MSG in the general population reveal no evidence of untoward effects. We recently conducted a multicenter DBPC challenge study in 130 subjects (the largest to date) to analyze the response of subjects who report symptoms from ingesting MSG. The results suggest that large doses of MSG given without food may elicit more symptoms than a placebo in individuals who believe that they react adversely to MSG. However, the frequency of the responses was low and the responses reported were inconsistent and were not reproducible. The responses were not observed when MSG was given with food.
R S Geha; A Beiser; C Ren; R Patterson; P A Greenberger; L C Grammer; A M Ditto; K E Harris; M A Shaughnessy; P R Yarnold; J Corren; A Saxon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1058S-62S     Citation Subset:  IM    
Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard University, Boston, MA, USA.
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MeSH Terms
Controlled Clinical Trials as Topic
Double-Blind Method
Epidemiologic Methods
Food Additives / adverse effects*
Multicenter Studies as Topic
Sodium Glutamate / adverse effects*
United States
United States Food and Drug Administration
Reg. No./Substance:
0/Food Additives; 0/Placebos; 142-47-2/Sodium Glutamate

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