Document Detail


Review: acute human models of gastric mucosal injury.
MedLine Citation:
PMID:  2979687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of acute human models of gastric mucosal injury has been stimulated by a need to understand more fully the problems of non-steroidal anti-inflammatory drugs but such models have other applications. None is ideal and they all share certain drawbacks. For none of them has a precise relationship to clinical events been established and they have all tended to be employed on a population of young healthy subjects who are not those at greatest clinical risk. Of individual methods mucosal potential difference is an indirect measure which is too often affected by other influences to be acceptable as a measure of mucosal injury when used alone, although it has some value as an adjunct to other measurements. Assay of DNA in gastric washings is a suitable technique for quantifying desquamation of gastric epithelial cells occurring in response to acute injury; on present evidence its significance is much more difficult to assess in the context of continuing challenge over several days. By contrast, measurement of microbleeding is more suitable for quantifying injury over several days of NSAID ingestion; little bleeding is recorded with a single acute challenge. Endoscopy can demonstrate macroscopic lesions which result from mucosal injury--injury which is quantified more easily and sensitively by measurements of cellular exfoliation or bleeding. Paradoxically, endoscopy's strength has been to underline the scientific weakness of acute models because it shows that it is rare for ulcers, which are the lesions of clinical concern to develop in these studies.
Authors:
C J Hawkey
Related Documents :
25446657 - Economic hardship and suicide mortality in finland, 1875-2010.
8775957 - Training model for nasal packing.
15784207 - The effect of center high mounted stop lamp (chmsl) on rear-end accidents in israel.
12900697 - Linear and angular head accelerations during heading of a soccer ball.
20953077 - Long term wbv measurements on vehicles travelling on urban paths.
19485397 - Use of reduced graphs to encode bioisosterism for similarity-based virtual screening.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  1     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1992-03-05     Completed Date:  1992-03-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  593-606     Citation Subset:  IM    
Affiliation:
Department of Therapeutics, University Hospital, Nottingham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Gastric Mucosa / pathology*
Humans
Stomach Ulcer / chemically induced,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Review: pancreatic enzyme replacement--applied physiology and pharmacology.
Next Document:  Contractility of human gallbladder muscle in vitro.