Document Detail

Review on Trypanosoma cruzi: Host Cell Interaction.
MedLine Citation:
PMID:  20811486     Owner:  NLM     Status:  In-Data-Review    
Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the feces of the insect while amastigotes and bloodstream trypomastigotes are released from the infected host cells of the vertebrate host after a complex intracellular life cycle. The recognition between parasite and mammalian host cell involves numerous molecules present in both cell types. Here, we present a brief review of the interaction between Trypanosoma cruzi and its host cells, mainly emphasizing the mechanisms and molecules that participate in the T. cruzi invasion process of the mammalian cells.
Wanderley de Souza; Tecia Maria Ulisses de Carvalho; Emile Santos Barrias
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  International journal of cell biology     Volume:  2010     ISSN:  1687-8884     ISO Abbreviation:  Int J Cell Biol     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517861     Medline TA:  Int J Cell Biol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Laboratório de Ultraestrutura Celular Hertha Meyer, CCS, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Bloco G, Ilha do Fundão, RJ 21941-902, Brazil.
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