Document Detail

A review of studies with chlorhexidine applied directly to the umbilical cord.
MedLine Citation:
PMID:  23254380     Owner:  NLM     Status:  MEDLINE    
Infection-related neonatal mortality due to omphalitis in developing country home births is an important public health problem. Three cluster randomized trials of 4% chlorhexidine applied to the umbilical cord stump from once to multiple times in the days following a home birth have evaluated this intervention compared with other types of cord care on the development of omphalitis and neonatalmortality. Each of the three studies showed significant reductions in either omphalitis, neonatal mortality, or both with the 4% chlorhexidine. However, the optimal dosing schedule remains uncertain. Although further studies are needed to clarify this issue, from the three studies it is now clear that with a minimum of one application of 4% chlorhexidine to the umbilical cord stump following delivery, the incidence of omphalitis and neonatal mortality can be reduced, especially in preterm newborns. This intervention, which is safe and inexpensive and requires minimal training and skill, should strongly be considered for adoption wherever home births occur.
Robert L Goldenberg; Elizabeth M McClure; Sarah Saleem
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  30     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-07     Completed Date:  2014-04-22     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-701     Citation Subset:  IM    
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MeSH Terms
Anti-Infective Agents, Local / administration & dosage*
Bacterial Infections / prevention & control*
Chlorhexidine / administration & dosage*
Developing Countries
Home Childbirth
Infant, Newborn
Infant, Newborn, Diseases / prevention & control*
Randomized Controlled Trials as Topic
Umbilical Cord / pathology*
Grant Support
Reg. No./Substance:
0/Anti-Infective Agents, Local; R4KO0DY52L/Chlorhexidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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