Document Detail

Review: Role of cerebral vessels in ischaemic injury of the brain.
MedLine Citation:
PMID:  21039751     Owner:  NLM     Status:  In-Data-Review    
J. Ogata, H. Yamanishi and H. Ishibashi-Ueda (2011) Neuropathology and Applied Neurobiology37, 40-55 Role of cerebral vessels in ischaemic injury of the brain This review discusses the pathological changes in the heart and vessels underlying brain ischaemic injury, with a major focus on atherosclerotic disease of the brain induced by lesions of the extracranial cervical and major intracranial arteries and small-vessel disease of the brain. The carotid bifurcation is the primary site for atherosclerotic changes, for which extensive clinical trials and pathological analyses on carotid endarterectomy specimens have been performed. Plaque rupture and erosion give rise to thrombus formation, which leads to brain ischaemic injury. These changes have much in common with atherosclerotic lesions of the subepicardial coronary arteries. Emboli of various types of particles are characteristics of brain ischaemic injury. Thrombi rich in fibrin and red blood cells (red thrombi) that develop in the cardiac chambers are common sources of cerebral emboli. Small-vessel disease of the brain induces fibrinoid necrosis, microaneurysm, fibrohyalinosis, lipohyalinosis and microatheroma, changes commonly associated with hypertension. The acute hypertensive small-vessel changes organize to create segmental arterial disorganization and deep small infarcts when they escape from rupture. Some specific vascular diseases responsible for brain ischaemic injury are briefly reviewed also.
J Ogata; H Yamanishi; H Ishibashi-Ueda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuropathology and applied neurobiology     Volume:  37     ISSN:  1365-2990     ISO Abbreviation:  Neuropathol. Appl. Neurobiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7609829     Medline TA:  Neuropathol Appl Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  40-55     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Neuropathology and Applied Neurobiology © 2011 British Neuropathological Society.
Hirakata General Hospital for Developmental Disorders Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan.
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