| Review: Pharmacodynamic monitoring of immunosuppression in kidney transplantation. | |
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MedLine Citation:
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PMID: 20649871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Advances in immunosuppressive therapies have improved kidney transplant outcomes. However, immunosuppressant drug-induced toxicities continue to reduce tolerability and impact patient and graft survival. A major ongoing challenge in kidney transplantation is to establish ways of tailoring immunosuppressant therapy so as to maintain efficacy while minimizing toxicity. Pharmacodynamic monitoring by direct measurement of immune cell function has the potential to personalize immunosuppression. The purpose of this review is to provide the clinician with an overview of the methodology and use of immune function monitoring in the field of kidney transplantation. |
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Authors:
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Katherine A Barraclough; Christine E Staatz; Nicole M Isbel; Steven J McTaggart |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nephrology (Carlton, Vic.) Volume: 15 ISSN: 1440-1797 ISO Abbreviation: Nephrology (Carlton) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9615568 Medline TA: Nephrology (Carlton) Country: Australia |
Other Details:
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Languages: eng Pagination: 522-32 Citation Subset: IM |
Affiliation:
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Department of Renal Medicine, University of Queensland at the Princess Alexandra Hospital, Queensland, Australia. katherine_barraclough@health.qld.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism Drug Monitoring / methods* Graft Rejection / immunology, prevention & control* Graft Survival / drug effects* Humans Immunosuppressive Agents / adverse effects, therapeutic use* Individualized Medicine Kidney Transplantation* / adverse effects Lymphocyte Activation / drug effects Monitoring, Immunologic* Predictive Value of Tests T-Lymphocyte Subsets / drug effects, immunology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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