Document Detail


Review: microglia in protein aggregation disorders: friend or foe?
MedLine Citation:
PMID:  23339288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microglia cells have been implicated, to some extent, in the pathogenesis of all of the common neurodegenerative disorders involving protein aggregation such as Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. However, the precise role they play in the development of the pathologies remains unclear and it seems that they contribute to the pathological process in different ways depending on the specific disorder. A better understanding of their varied roles is essential if they are to be the target for novel therapeutic strategies.
Authors:
S M Gentleman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Neuropathology and applied neurobiology     Volume:  39     ISSN:  1365-2990     ISO Abbreviation:  Neuropathol. Appl. Neurobiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-07-24     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  7609829     Medline TA:  Neuropathol Appl Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Copyright Information:
© 2013 British Neuropathological Society.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Microglia / immunology,  pathology*
Neurodegenerative Diseases / immunology,  pathology*
Grant Support
ID/Acronym/Agency:
AG12411/AG/NIA NIH HHS; P01 AG012411/AG/NIA NIH HHS
Comments/Corrections

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