| Inflammatory markers, cholesterol and statins: pathophysiological role and clinical importance. | |
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MedLine Citation:
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PMID: 20868311 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Statins are one of the most important medications in cardio-vascular diseases since they block cholesterol synthesis by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme A reductase and thus reduce low density lipoprotein concentrations. In the last years, numerous pleiotropic properties of statins have been described, beyond their well-known lipid lowering function. In particular, they are able to modulate inflammation, which plays a pivotal role in the atherosclerotic process. Several trials have shown a direct correlation between statin therapy and lower C-reactive protein concentrations. Moreover, a large body of pathophysiological studies has demonstrated that statins lower cytokine concentrations and inhibit recruitment, migration and cell adhesion to endothelium by attenuating chemokine production. They also inhibit inflammatory pathways regulated by proteins as Ras and Rho, and increase nitric oxide production which exerts a protective effect on endothelium. In addition to reducing inflammation in coronary atherosclerosis, statins also have beneficial effects in chronic inflammatory and autoimmune diseases, such as psoriasis, and they could induce clinical improvement. Statins seem to exert benefits even in settings of infection. These results suggest that initiating and monitoring statin therapy on the basis of inflammatory markers, in particular C-reactive protein, may improve cardiovascular prevention and treatment. |
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Authors:
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Luigi Marzio Biasucci; Gina Biasillo; Antonella Stefanelli |
Publication Detail:
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Type: Journal Article Date: 2010-09-27 |
Journal Detail:
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Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 48 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
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Languages: eng Pagination: 1685-91 Citation Subset: IM |
Affiliation:
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Institute of Cardiology, Catholic University of Sacred Heart, Rome, Italy. lmbiasucci@virgilio.it |
Export Citation:
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment In:
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Clin Chem Lab Med. 2010 Dec;48(12):1683-4
[PMID:
21105860
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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