Document Detail


A review of genetics, arterial stiffness, and blood pressure in African Americans.
MedLine Citation:
PMID:  22492025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of hypertension in African Americans in the USA is among the highest in the world and increasing. The identification of genes and pathways regulating blood pressure in African Americans has been challenging. An early predictor of hypertension is arterial stiffness. The prevalence of arterial stiffness is significantly higher in African Americans compared to Caucasians. Approximately 20 % of the variance in arterial stiffness is estimated to be heritable. Identifying genes and biological pathways regulating arterial stiffness may provide insight into the genetics underlying the increased risk of hypertension in African Americans. This paper reviews the genetic findings to date in the area of arterial stiffness and blood pressure in African Americans with an emphasis on the current limitations and new efforts to move the field forward.
Authors:
Jennifer L Hall; Daniel A Duprez; Ana Barac; Stephen S Rich
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-04-11
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  5     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-11     Completed Date:  2012-09-10     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  302-8     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-106 NHH, 312 Church Street, Minneapolis, MN 55455, USA. jlhall@umn.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans / genetics*
Arteries / pathology*,  physiopathology
Blood Pressure / genetics*
Compliance
Genetic Predisposition to Disease
Heredity
Humans
Hypertension / ethnology,  genetics*,  pathology,  physiopathology
Phenotype
Prevalence
Risk Assessment
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
R01 HL081715/HL/NHLBI NIH HHS; R21 HL104596/HL/NHLBI NIH HHS
Comments/Corrections

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