Document Detail


"Review of Findings in Prophylactic Gynaecologic Specimens in Lynch Syndrome with Literature Review and Recommendations for Grossing"
MedLine Citation:
PMID:  24495259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Prophylactic hysterectomy with bilateral salpingo-oophorectomy is increasingly being undertaken in patients with Lynch syndrome (LS). The pathological features in such specimens are not well described and, unlike the SEE-FIM protocol for salpingo-oophorectomy specimens in BRCA 1/2 mutation carriers and the gastrectomy grossing protocols for patients with CDH-1 (E-cadherin) mutations, guidelines have not been devised for the grossing of prophylactic gynaecologic specimens from LS patients. We aimed to review the pathological findings in a series of prophylactic gynaecologic specimens from LS patients and develop guidelines for the grossing of these specimens.
METHODS AND RESULTS: We reviewed the pathological findings in 25 prophylactic gynaecologic specimens from LS patients and audited the grossing protocols in different centres across Ontario, Canada. We found a 32% incidence of endometrial carcinoma or a precursor lesion; the 2 endometrial cancers identified were low grade, low stage endometrioid adenocarcinomas. To address the absence of guidelines for pathological examination, we undertook a literature review of gynaecologic malignancies and incidental findings in prophylactic specimens in LS patients.
CONCLUSION: We provide recommendations regarding the grossing of such specimens which includes in toto examination of the lower uterine segment, endometrium, ovaries and fallopian tubes with representative sampling of the cervix. This article is protected by copyright. All rights reserved.
Authors:
Michelle R Downes; Ghassan Allo; W Glenn McCluggage; Keiyan Sy; Sarah E Ferguson; Melyssa Aronson; Aaron Pollett; Steve Gallinger; Elaine Bilbily; Pat Shaw; Blaise A Clarke
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-4
Journal Detail:
Title:  Histopathology     Volume:  -     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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