Document Detail

Review of the Fifth American College of Chest Physicians Consensus Conference on Antithrombotic Therapy: outpatient management for adults.
MedLine Citation:
PMID:  10478987     Owner:  NLM     Status:  MEDLINE    
The recommendations of the Fifth American College of Chest Physicians (ACCP) Consensus Conference on Antithrombotic Therapy are reviewed, with a focus on outpatient anticoagulation management in adults. Numerous therapeutic recommendations have changed since the Fourth ACCP Consensus Conference on Antithrombotic Therapy. The system of grading recommendations has been modified to emphasize clinically important differences and to take into account the benefit-risk ratio of each treatment option. The International Normalized Ratio (INR) goal is now expressed as a specific target value within a range rather than simply an INR range. The recommendations of the fifth conference cover initiation of warfarin therapy, hemorrhagic complications, management of excessive anticoagulation, interruption of warfarin therapy for patients requiring surgery, nonvalvular atrial fibrillation, cardioversion in patients with atrial fibrillation, valvular heart disease, mechanical and biological prosthetic heart valves, coronary artery disease, saphenous vein and internal mammary artery bypass grafts, peripheral arterial occlusive disease, prevention of venous thromboembolism, treatment of venous thromboembolism, stroke prevention in patients with cerebrovascular disease, and pregnancy. Since the fourth consensus conference, new anticoagulation therapies and indications have emerged; the recommendations of the Fifth ACCP Consensus Conference on Antithrombotic Therapy have provided practitioners with a resource of immense value.
G P Sachdev; K D Ohlrogge; C L Johnson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists     Volume:  56     ISSN:  1079-2082     ISO Abbreviation:  Am J Health Syst Pharm     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-29     Completed Date:  1999-10-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9503023     Medline TA:  Am J Health Syst Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1505-14     Citation Subset:  IM    
Rockford Veterans Affairs Primary Care Clinic, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
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MeSH Terms
Anticoagulants / adverse effects,  therapeutic use*
Cardiovascular Diseases / drug therapy
Fibrinolytic Agents / adverse effects,  therapeutic use*
Middle Aged
Thrombosis / drug therapy*
Warfarin / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Anticoagulants; 0/Fibrinolytic Agents; 81-81-2/Warfarin
Comment In:
Am J Health Syst Pharm. 2000 Feb 1;57(3):220, 223   [PMID:  10674775 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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