Document Detail

Review: Fetal antigens--identity, origins, and influences on the maternal immune system.
MedLine Citation:
PMID:  21211836     Owner:  NLM     Status:  MEDLINE    
Pregnancy induces priming of the maternal cellular and humoral immune systems. The paternally-inherited fetal antigens that influence maternal T and B cells include both major and minor histocompatibility antigens - the same antigens that are problematic in allotransplantation. Animal models have facilitated our understanding of the lymphocyte responses to fetal antigens, and our appreciation of the parallel response in pregnant women is increasing. The physiologic properties of the placenta as well as trafficking of cells between mother and fetus allow ample opportunity for sampling of fetal proteins by the maternal immune system. Here, the current state of knowledge of fetal antigen-specific lymphocyte responses in pregnancy is reviewed.
M G Petroff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-05
Journal Detail:
Title:  Placenta     Volume:  32 Suppl 2     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-28     Completed Date:  2011-06-07     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S176-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Fetus / immunology*
Immune Tolerance / immunology*
Isoantigens / immunology
Placenta / immunology
Pregnancy / immunology*
Grant Support
P01 HD049480-04/HD/NICHD NIH HHS; P20 RR16475/RR/NCRR NIH HHS; R01 045611//PHS HHS; R01 HD045611/HD/NICHD NIH HHS; R01 HD045611-07A2/HD/NICHD NIH HHS; R21 HD062879/HD/NICHD NIH HHS; R21 HD062879-01/HD/NICHD NIH HHS
Reg. No./Substance:

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