Document Detail


Review of Ets1 structure, function, and roles in immunity.
MedLine Citation:
PMID:  23288305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an aggressive behavior in tumors that express it at high levels. Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.
Authors:
Lee Ann Garrett-Sinha
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-05
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  70     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-27     Completed Date:  2013-11-04     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3375-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Autoimmunity*
B-Lymphocytes / immunology*
Cell Transformation, Neoplastic
Chickens
Gene Expression Regulation, Neoplastic*
Humans
Killer Cells, Natural / immunology
Mice
Opossums
Protein Isoforms / immunology,  physiology
Proto-Oncogene Protein c-ets-1 / immunology,  physiology*
SUMO-1 Protein / metabolism
T-Lymphocytes / immunology
Ubiquitin / metabolism
Grant Support
ID/Acronym/Agency:
AI085127/AI/NIAID NIH HHS; AI099422/AI/NIAID NIH HHS; R01 AI085127/AI/NIAID NIH HHS; R21 AI099422/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/ETS1 protein, human; 0/Protein Isoforms; 0/Proto-Oncogene Protein c-ets-1; 0/SUMO-1 Protein; 0/SUMO1 protein, human; 0/Ubiquitin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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