Document Detail

A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update.
MedLine Citation:
PMID:  20558227     Owner:  NLM     Status:  MEDLINE    
This review of human studies of caffeine and reproductive health published between January 2000 and December 2009 serves to update the comprehensive review published by Leviton and Cowan (2002). The adverse reproductive outcomes addressed in this review include: (1) measures of subfecundity; (2) spontaneous abortion; (3) fetal death; (4) preterm birth; (5) congenital malformations; and (6) fetal growth restriction. Methodologic challenges and considerations relevant to investigations of each reproductive endpoint are summarized, followed by a brief critical review of each study. The evidence for an effect of caffeine on reproductive health and fetal development is limited by the inability to rule out plausible alternative explanations for the observed associations, namely confounding by pregnancy symptoms and smoking, and by exposure measurement error. Because of these limitations, the weight of evidence does not support a positive relationship between caffeine consumption and adverse reproductive or perinatal outcomes.
Jennifer David Peck; Alan Leviton; Linda D Cowan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-15
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2549-76     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
University of Oklahoma Health Sciences Center, College of Public Health, USA.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology
Abortion, Spontaneous / chemically induced,  epidemiology
Caffeine / adverse effects*
Central Nervous System Stimulants / adverse effects*
Fertility / drug effects
Fetal Death / chemically induced,  epidemiology
Fetal Growth Retardation / chemically induced
Infertility / chemically induced,  epidemiology
Obstetric Labor, Premature / chemically induced
Reproduction / drug effects*
Smoking / physiopathology
Reg. No./Substance:
0/Central Nervous System Stimulants; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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