Document Detail

Efficacy and tolerability of olmesartan/amlodipine combination therapy in patients with mild-to-severe hypertension: focus on 24-h blood pressure control.
MedLine Citation:
PMID:  20921092     Owner:  NLM     Status:  MEDLINE    
European guidelines recommend that treating patients with hypertension to blood pressure (BP) goal is an important target for cardiovascular (CV) risk reduction. However, office BP may be a suboptimal target, given its limitations. Indeed, there is evidence that 24-h ambulatory BP monitoring (ABPM) parameters may score better in this regard, representing more accurate predictors of CV risk. In particular, mean 24-h BP and BP variability both correlate closely with hypertension end-organ damage and rate of CV events, which suggests that antihypertensive therapy should provide smooth BP control over the full 24-h dosing interval. The use of ABPM has demonstrated that fixed-dose combination therapy, comprising agents with complementary mechanisms of action, may overcome the challenge of suboptimal BP control by providing improvements in antihypertensive efficacy and tolerability throughout the 24-h period. Olmesartan/amlodipine is one of the latest combination therapies to be approved, and a number of large clinical trials have demonstrated the efficacy and tolerability of this combination in patients with mild-to-severe hypertension. Furthermore, recent ABPM studies of olmesartan/amlodipine-based treatment algorithms have shown the satisfactory 24-h antihypertensive efficacy of this fixed-dose combination. This review provides an overview of recent clinical data on the efficacy and tolerability of fixed-dose olmesartan/amlodipine combination therapy for the treatment of mild-to-severe hypertension, with a focus on sustained 24-h BP control.
Gianfranco Parati; Juan Eugenio Ochoa; Carlos Ramos; Satoshi Hoshide; Laura Lonati; Grzegorz Bilo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Therapeutic advances in cardiovascular disease     Volume:  4     ISSN:  1753-9455     ISO Abbreviation:  Ther Adv Cardiovasc Dis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101316343     Medline TA:  Ther Adv Cardiovasc Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-13     Citation Subset:  IM    
Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Department of Cardiology, S. Luca Hospital, IRCCS Istituto Auxologico Italiano, via Spagnoletto, 3 20149 Milan, Italy.
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MeSH Terms
Amlodipine / administration & dosage*,  adverse effects
Angiotensin II Type 1 Receptor Blockers / administration & dosage*,  adverse effects
Antihypertensive Agents / administration & dosage*,  adverse effects
Blood Pressure / drug effects,  physiology
Circadian Rhythm / physiology
Drug Therapy, Combination
Hypertension / diagnosis,  drug therapy*
Imidazoles / administration & dosage*,  adverse effects
Severity of Illness Index
Tetrazoles / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Imidazoles; 0/Tetrazoles; 0/olmesartan; 88150-42-9/Amlodipine

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