Document Detail

Review: Dupuytren's disease in Asia and the migration theory of Dupuytren's disease.
MedLine Citation:
PMID:  20795961     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The presentation of a Chinese patient with unilateral Dupuytren's disease (DD) prompted a literature search and a review of the epidemiology of DD in the Asian population as it has never been cumulatively reported. The purpose of this paper is to review all the reported cases of DD in the literature and aetiological links to DD elsewhere.
METHODS: The literature was searched with a wide variety of terms, and subsequent references were analysed and further references investigated for other reported cases of DD in the Asian population.
RESULTS: This review found 595 cases and has shown that DD is present to a variable extent in China (96 cases), Thailand (19 cases), Vietnam (one case), India (15 cases) and Japan (474 cases). A total of 54% had bilateral disease. Risk factors (diabetes, trauma, epilepsy, alcoholism, manual labour) were reportedly present in 65% of the patients, and a positive family history was reported in 9%. The average patient age was 67 years.
CONCLUSION: This review shows that there is a low but significant incidence of DD across Asia, which supports the hypothesis of a widespread genetic susceptibility to the disease. Therefore, the prevalence of DD in this community is not likely due to sporadic genetic mutation as previously presumed but rather individual genetic susceptibility and that risk factors play a major role in the expression of DD in this population.
David Slattery
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  ANZ journal of surgery     Volume:  80     ISSN:  1445-2197     ISO Abbreviation:  ANZ J Surg     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-21     Revised Date:  2011-06-10    
Medline Journal Info:
Nlm Unique ID:  101086634     Medline TA:  ANZ J Surg     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  495-9     Citation Subset:  IM    
Department of Orthopaedic Surgery, Alfred Hospital, Hawthorn, Victoria, Australia.
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MeSH Terms
Age Distribution
Age of Onset
Asia / epidemiology
China / epidemiology
Dupuytren Contracture / diagnosis*,  epidemiology*
Emigration and Immigration*
India / epidemiology
Japan / epidemiology
Middle Aged
Sex Distribution
Comment In:
ANZ J Surg. 2011 May;81(5):393   [PMID:  21518200 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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