| Review: Does vitamin E have a role in treatment and prevention of anemia's? | |
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MedLine Citation:
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PMID: 21454177 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Vitamin E is a highly effective fat-soluble vitamin with a variety of cellular membrane stabilizing-antioxidant and non-antioxidant functions. Vitamin E has been suggested to prevent the oxidation of polyunsaturated fatty acids in red blood cell (RBC) membrane, thus inhibiting the premature erythrocytelysis. Animal studies have shown that treatment with vitamin E results in increased number of colony forming units of erythroid precursors, enhanced erythropoiesis and improved blood hemoglobin levels in these animals. Several clinical trials have indicated that vitamin E might be used therapeutically as a potential erythropoietic agent for decreasing the premature erythrocyte hemolysis by reducing the fragility of erythrocytes. By this way, it improves the post-supplemental blood hemoglobin and hematocrit levels in some of the anemic human subjects, including low birth weight premature infants, patients suffering from various types of inherited hemolytic anemia, chronic renal failure patients on hemodialysis and apparently healthy mildly anemic subjects. |
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Authors:
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Tanveer Jilani; Mohammad Perwaiz Iqbal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 24 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 237-42 Citation Subset: IM |
Affiliation:
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Department of Biological & Biomedical Sciences, Aga Khan University, Stadium Road, P.O. Box-3500, Karachi, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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