Document Detail


Review. Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents.
MedLine Citation:
PMID:  17436571     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.
Authors:
Leonard Amaral; Helga Engi; Miguel Viveiros; Joseph Molnar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  21     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-07-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  237-44     Citation Subset:  IM    
Affiliation:
Unit of Mycobacteriology, UPMM, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-088 Lisboa, Portugal. lamaral@ihmt.unl.pt
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / metabolism*
Anti-Bacterial Agents / pharmacology*
Antineoplastic Agents / pharmacology*
Bacteria / drug effects
Bacterial Physiological Phenomena*
Cell Line, Tumor
Drug Resistance, Bacterial
Drug Resistance, Multiple*
Drug Resistance, Neoplasm
Humans
Neoplasms / drug therapy,  metabolism,  physiopathology*
Chemical
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Anti-Bacterial Agents; 0/Antineoplastic Agents

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