| Review. Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents. | |
| | |
MedLine Citation:
|
PMID: 17436571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR. |
| | |
Authors:
|
Leonard Amaral; Helga Engi; Miguel Viveiros; Joseph Molnar |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: In vivo (Athens, Greece) Volume: 21 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2007 Mar-Apr |
Date Detail:
|
Created Date: 2007-04-17 Completed Date: 2007-07-20 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
|
Languages: eng Pagination: 237-44 Citation Subset: IM |
Affiliation:
|
Unit of Mycobacteriology, UPMM, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-088 Lisboa, Portugal. lamaral@ihmt.unl.pt |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ATP-Binding Cassette Transporters
/
metabolism* Anti-Bacterial Agents / pharmacology* Antineoplastic Agents / pharmacology* Bacteria / drug effects Bacterial Physiological Phenomena* Cell Line, Tumor Drug Resistance, Bacterial Drug Resistance, Multiple* Drug Resistance, Neoplasm Humans Neoplasms / drug therapy, metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/ATP-Binding Cassette Transporters; 0/Anti-Bacterial Agents; 0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis and cytotoxic activity of certain 2,3,4,9-tetrahydrofuro [2,3-b] quinolin-3,4-dione and et...
Next Document: Understanding interactions between and among apoptosis inducing pathways in tumor cells.