| Nature and consequences of mammalian brain and CSF efflux transporters: four decades of progress. | |
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MedLine Citation:
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PMID: 19860860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the last 40 years, especially with the application of new neurochemical and molecular biological techniques, there has been explosive progress in understanding how certain ligands and drugs are transported across the blood-brain barrier and choroid plexus out of brain and CSF. In the CNS, there are several separate efflux transporters with very broad specificity that are responsible for much of the efflux transport. This review focuses on three such transporters: organic acid transporter-3, peptide transporter-2 and P-glycoprotein for which there is substantial new information including 'knockout' models in mice and, in one case, dogs. Moreover, the structural biology and transport mechanism of P-glycoprotein at 3.8 angstroms is described. The overall objective is to show how this new knowledge provides a more thorough understanding (e.g., of molecular mechanisms) of efflux transport and in several cases leads to clinically relevant information that allows better treatment of certain CNS disorders (e.g., meningitis and brain cancer). |
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Authors:
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Reynold Spector |
Publication Detail:
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Type: Journal Article; Review Date: 2009-10-26 |
Journal Detail:
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Title: Journal of neurochemistry Volume: 112 ISSN: 1471-4159 ISO Abbreviation: J. Neurochem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-02-08 Revised Date: 2010-04-19 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: England |
Other Details:
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Languages: eng Pagination: 13-23 Citation Subset: IM |
Affiliation:
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Department of Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA. mspec007@verizon.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / metabolism, physiology Brain / metabolism*, physiology Central Nervous System Diseases / cerebrospinal fluid*, metabolism Humans Membrane Transport Proteins / cerebrospinal fluid*, physiology Protein Transport / physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Membrane Transport Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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